Build your professional network on facebook via our app Go to app
 
<< Prev  8 of 14 in Topic  Next >>
 

Is There a Future for Anticancer Cell Cycle Kinase Inhibitors?

Created by : Bindu Narayan, Product Development Manager, Care Biomedicals  | 07 20 2009 06:41:09 +0000
Industry : BiotechnologyFunctional Area : Growth(Strategy & Execution)
Keywords : enzymes molecules dna replication anticancer cell cycle kinase inhibitors malignant cell proliferation cell divisions cell growth cda
Activity:  198 views;  last activity : 07 06 2010 20:18:09 +0000

Dear friends, several families of enzymes known as cell cycle kinases regulate the life cycle of normal cells. These enzymes work hand-in-hand with a class of molecules called cylins that have no enzymatic activity. The individual steps of cell division must carefully be controlled to ensure that all the required molecular components are in place before proceeding to the next step. This control ensures an orderly division of the cell with high fidelity DNA replication. When CDK control breaks down due to molecular damage or mutation, the cell cycle may spin out of control resulting in the unregulated cell growth and division that characterizes cancer cells.

Although several molecules that inhibit cell cycle kinases have been developed and clinically screened as potential anticancer agents, none of these has been approved for commercial use, and an effective strategy to specifically control malignant cell proliferation has yet to be established

According to you, is there any future for anticancer cell cycle Kinase inhibitors ?

Please post your comments.....

  
 Refer 81
Share
 
 
  Rate : 
 
 
Yes Vs No
3
 
 
 
 
0
2
0
Support   Support
Top Argument
1
0

It has been observed  that it is effective at causing cell cycle arrest and inhibiting DNA damage-induced apoptotic events such as cytochrome c release, mitochondrial membrane depolarization, and activation of the caspase cascade. These observations suggest that by blocking dysregulated cell cycle progression, CDK inhibitors can influence the sensitivity of the mitochondria to proapoptotic signals in DNA damage-induced cancer cells.like monoclonal antibodies this kind of treatment style can b a big leap forward in the medical science.Only the cost has to b with in the reach of the patients.That is my formost concern.
By AMIT KATOCH, Freelancer  07 22 2009 06:21:33 +0000
 
0
0

In my view, the future approaches should combine the lessons learned from early work using small-molecule inhibitors with the recent increased understanding of the deregulation of cell cycle protein kinases in cancer. In the recent years, the chemical inhibition has emerged as a powerful approach to advance our understanding of these kinases and numerous inhibitors are being developed as potential anticancer drugs.
By Bindu Narayan, Product Development Manager, Care Biomedicals  | 07 20 2009 06:47:29 +0000
Argue for "Yes"
Argue for "No"
 Found the debate "Is There a Future for Anticancer Cell Cycle Kinase Inhibitors?"  interesting ?  Suggest to your connections and communities  
 
Viewers also viewed
Is radio-wave of cell phone (mobile phone) harmful for living being?  
 
1534 referals 35 arguments, 1324 views
By Lori Bongiorno How much radiation does your cell phone emit? It's easy to find out the answer...
 
479 referals 15 comments, 11410 views
more...  
 
Sponsored Jobs
More From Author
Keep sweet cravings at bay for a healthier life The festival season just ended and all of us have loaded ourselves with lots and lots of sweets. This is satisfying and good at first but then the after effects can make us feel terrible. Here are...
We are in between such a season where the probability of falling sick is maximum. Sometimes it rains, sometimes it is cold and sometimes it is the hot hot sun over head. So what are you doing to stay safe? Share your ideas on staying away from...
We have seen many emotional as well as motivational songs and videos. Many such links keep on circulation on web. We get many mails which have a motivational story. Do you think such things help people. Or a person always needs to motivate himself?
more...