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Industry : Biotechnology Functional Area : Innovation
Keywords :

biomarkers

predict age

Activity:  10 comments  480 views  last activity : 07 06 2010 20:18:04 +0000
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hello friends,

This is a very interesting article and a new discovery. So I thought I would share it with you all.

Biomarkers of aging identified

In a first of its kind study, scientists at the Buck Institute for Age Research have uncovered biomarkers of aging, which can predict both chronological and physiological age.
Biomarkers are biochemical features that can be used to measure the progress of disease or the effects of treatment.

The scientists conducted the study by using nematode worms, microarrays which measure changes in gene expression, and complex computer algorithms.

And they believe that the step could help them identify similar biomarkers in humans, which would provide a means of scientifically validating anti-aging therapies. Chronological and physiological age are rarely in sync. Determining chronological age in both worms and humans is easy - count forward from birth. Determining physiological age remains subjective - based on how someone looks or functions.

Some 70 year old humans function at the level of those in their 50's, others become frail elderly sooner than would be expected. C. elegans, the nematode worm, is a similar creature.

Having an average lifespan of three weeks, some nematodes remain active much longer than then their similarly-aged brethren, while others show signs of premature aging (lack of symmetrical appearance, uncoordinated motion, and the need to be prodded into movement).

The researchers could predict the age of the worms by doing whole-genome expression profiles of 104 individual wild-type worms covering the entire nematode lifespan and correlating that profiling with age-related behaviour and survival.

The study revealed a suite of genes that are actively involved in the aging process.

"This is the first evidence that physiological age can be predicted non-subjectively. This is a first step; our results were not perfect, but we were able to predict the ages of the animals 70% of the time, which is far better than anything that has been done before," said Simon Melov, PhD, Buck faculty member and lead author of the study.

The study has implications for age research in humans.

Examining biomarkers over time would provide a scientific baseline for clinical trials of anti-aging medicines, which is currently impossible to determine given the lengthy lifetime of human beings.

The technology would also provide a means of determining whether an individual is aging faster or slower than would normally be expected.

I hope you all LIked it.

But I have a question here. What impact will this have in our life. Is it good to know about our age well before?

 Top Comment : Bindu Narayan   | 05 20 2009 10:36:37 +0000
Hi Sovan, Really nice article.. Yes this is a critical issue..might have ethical problems also.. I would say let it happen..we can manage the consequences later.. we never know how beneficial it might prove to humanity..!!
 
10 comments on "Biomarkers to predict your age now...!!"
  Commented by  Sanjay Saha, Product/Brand Manager, Dr Reddy Labs    | 08 28 2009 14:57:58 +0000
Hi Sovan, nice article. Of course this is a very serious issue. Everybody need to concentrate on this issue seriously...Thanks for sharing...
  Commented by  FAROOQ SYED, Pharmacist/Chemist/Bio Chemist, ASTON UNIVERSITY    | 08 28 2009 14:36:20 +0000
Helo friends, already we have some biomarkers like TELOMERASE as a biomarker for aging and it also a very hot field in the biomedical research
  Commented by  Sovan Maiti, Product Development Manager, Care Biomedicals    | 05 27 2009 13:58:33 +0000
I was just asking whether it is good to know our age before itself and  will it face ethical challenges if some one makes changes, Dorina???
  Commented by  Dorina Grossu, student, Centennial College    | 05 27 2009 12:39:51 +0000
Rating : +1 
Hi Sovan, are you asking if it is ethical to make changes!
  Commented by  BEENA AGARWAL, Head/VP/GM-Corporate Planning/Strategy, ANADI HI TECH AGRO PVT LTD    | 05 25 2009 16:54:10 +0000
Rating : +1 
Hey its nice information.
The findings have major implications for age research in humans. Examining biomarkers over time would provide a scientific baseline for clinical trials of anti-aging medicines, which is currently impossible to determine given the lengthy lifetime of human beings. The technology would also provide a means of determining whether an individual is aging faster or slower than would normally be expected. 
  Commented by  Jyoti Rath, Sr. Associate, Barclays    | 05 25 2009 13:09:58 +0000
Rating : +1 
very nice insight Mr. Sovan...thanks for sharing..
  Commented by  Viktor Stephen, COO, Business Mashup/Partner Get.Next.Job    | 05 23 2009 16:47:05 +0000
Rating : +1 
Interesting, yet controversial post. Physiological age need never be in sync with chronological age. 
  Commented by  varsha, technical manager(QMS)    | 05 20 2009 16:50:14 +0000
Rating : +1 
very nice sharing..
Rating : +2 
definitely its a arguable topic, but i will say it is good to know about your age.we have to look its positve side then only we can use it in better way for humans .
  Commented by  Bindu Narayan, Product Development Manager, Care Biomedicals    | 05 20 2009 10:36:37 +0000
Rating : +1 
Hi Sovan,
Really nice article.. 
Yes this is a critical issue..might have ethical problems also.. 
I would say let it happen..we can manage the consequences later.. we never know how beneficial it might prove to humanity..!!
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