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Industry : Pharmaceuticals Functional Area : Innovation
Activity:  6 comments  140 views  last activity : 08 06 2010 09:02:30 +0000
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Scientists have cracked the genetic secrets of high cholesterol, paving the way for new drugs to beat heart disease.

Britain's biggest killer, heart disease affects 2.5million people and claims more than 250 lives each day.

The amount of artery-clogging cholesterol and other fats in the blood greatly affects the odds of heart attacks and other problems, but until now, little was known about the genes that control their levels.

More than 100 researchers from 17 countries, including the UK, studied the DNA of more than 100,000 people of European ancestry. This flagged up 95 genetic changes linked to blood fats, or lipids, and heart disease, the journal Nature reports.

Further experiments showed that many of the genes also contribute to heart problems in other ethnic groups from around the world. Working out exactly how these genes raise or lower cholesterol and other harmful fats could lead to new drugs that could benefit millions.

Although statins are widely used to lower cholesterol, side-effects lead to many stopping taking them, and some doctors say that while the drugs benefit men, there is scant evidence they ward off heart disease in women.

Researcher Dr Christopher O'Donnell, of the National Heart, Lung and Blood Institute in the US, said: 'The new findings point us to specific genetic signposts that allow us to understand why many people from all walks of life have abnormal levels of cholesterol and other blood lipids that lead to heart disease.

'What's really exciting about this work is that we are moving from discovery to understanding brand new information about how genes alter the lipids that lead to heart disease.'

Francis Collins, one of the world's leading geneticists, said: 'Genetic studies that survey a wide variety of human populations are a powerful tool for identifying hereditary factors in health and disease.

'These results help refine our course for preventing and treating heart disease, a health problem that affects millions.'

 Top Comment : yogesh deshpande   | 08 05 2010 10:22:02 +0000
Thanks for the Information mr.Gupta. A NEEDLE CAN SAVE THE LIFE OF A STROKE PATIENT - From a Chinese Professor. Keep a syringe or needle in your home to do this... It's amazing and an unconventional way of recovering from stroke, read it through it can help somebody one way. This is amazing. Please keep this very handy. Excellent tips. Do take a minute to read this. You'll never know, ones life may depend on you. My father was paralysed and later died from the result of a stroke. I wish I knew about this first aid before. When stroke strikes, the capillaries in the brain will gradually burst. (Irene Liu) When a stroke occurs, stay calm. No matter where the victim is, do not move him/her. Because, if moved, the capillaries will burst. Help the victim to sit up where he/she is to prevent him/her from falling over again and then the bloodletting can begin. If you have in your home an injection syringe that would be the best. Otherwise, a sewing needle or a straight pin will do. 1. Place the needle/pin over fire to sterilize it and then use it to prick the tip of all ......10 fingers. 2. There are no specific acupuncture points, just prick about an mm from the fingernail. 3. Prick till blood comes out.. 4. If blood does not start to drip, then squeeze with your fingers. 5. When all 10 digits is bleeding, wait a few minutes then the victim will regain consciousness. 6. If the victim's mouth is crooked, then pull on his ears until they are red. 7. Then prick each earlobe twice until two drops of blood comes from each earlobe. After a few minutes the victim should regain consciousness. Wait till the victim regains his normal state without any abnormal symptoms then take him to the hospital. Otherwise, if he was taken in the ambulance in a hurry to the hospital, the bumpy trip will cause all the capillaries in his brain to burst. If he could save his life, barely managing to walk, then it is by the grace of his ancestors. 'I learned about letting blood to save life from Chinese traditional doctor, Ha Bu Ting, who lives in Sun Juke. Furthermore, I had practical experience with it. Therefore, I can say this method is 100% effective. In 1979, I was teaching in Fung Gaap College in Tai Chung. One afternoon, I was teaching a class when another teacher came running to my classroom and said in panting, 'Ms Liu, come quick, our supervisor has had a stroke!'. I immediately went to the 3rd floor. When I saw our supervisor, Mr. Chen Fu Tien, his colour was off, his speech was slurred, his mouth was crooked - all the symptoms of a stroke. Immediately asked one of the practicum students to go to the pharmacy outside the school to buy a syringe, which I used to prick Mr. Chen's10 fingers tips. When all 10 fingers were bleeding (each with a pea-sized drop of blood), after a few minutes, Mr. Chen's face regained its colour and his eyes' spirit returned, too. But his mouth was still crooked. So I pulled on his ears to fill them with blood. When his ears became red, I pricked his right earlobe twice to let out two drops of blood. When both earlobes had two drops of blood each, a miracle happened. Within 3-5 minutes the shape of his mouth returned to normal and his speech became clear. We let him rest for a while and have a cup of hot tea, then we helped him go down the stairs, drove him to Wei ah Hospital. He rested one night and was released the next day to return to school to teach. Everything worked normally. There were no ill after effects. On the other hand, the usual stroke victim usually suffers Irreparable bursting of the brain capillaries on the way to the hospital. As a result, these victims never recover.' (Irene Liu)Therefore, stroke is the second cause of death. The lucky ones will stay alive but can remain paralyzed for life. It is such a horrible thing to happen in one's life. If we can all remember this bloodletting method and start the life saving process immediately, in a short time, the victim will be revived and regain 100% normality. IF POSSIBLE PLEASE FORWARD THIS AFTER READING. YOU NEVER KNOW IT MAY HELP SAVE A LIFE FROM STROKE. SPARE A COUPLE OF MINUTES TO FORWARD THIS MAIL. LIFE IS PRECIOUS.
 
6 comments on "GENETIC SECRETS OF HIGH CHOLESTEROL--New dimention in treating Heart disease"
  Commented by  vigneshwar reddy, B.Sc student, bio technology    | 08 07 2010 10:48:59 +0000
Thanks for sharing that information sir
  Commented by  Sovan Maiti, Product Development Manager, Care Biomedicals    | 08 06 2010 09:01:16 +0000
Very informative article ..... thanks for sharing....  :) 
  Commented by  Dr Ali Ahmad, Medical Superintendent/Director, Surbhi Hospital    | 08 05 2010 16:24:39 +0000
Rating : +1 
Thanks for the referral Mr Suresh
Rating : +1 
Thanks for the Information mr.Gupta. 

A NEEDLE CAN SAVE THE LIFE OF A STROKE PATIENT -


 From a Chinese Professor.


 Keep a syringe or needle in your home to do this...



 It's amazing and an unconventional way of recovering from stroke, read it through it can help somebody one way.

 This is amazing. Please keep this very handy. Excellent tips.


 Do take a minute to read this. You'll never know, ones life may depend on you.

 My father was paralysed and later died from the result of a stroke. I wish I knew about this first aid before.

 When stroke strikes, the capillaries in the brain will gradually burst. (Irene Liu)

 When a stroke occurs, stay calm.

 No matter where the victim is, do not move him/her.
 Because, if moved, the capillaries will burst.

 Help the victim to sit up where he/she is to prevent him/her from falling over again and then the bloodletting can begin.

 If you have in your home an injection syringe that would be the best.
Otherwise, a sewing needle or a straight pin will do.

 1. Place the needle/pin over fire to sterilize it and then use it to prick the tip of all ......10 fingers.
 2. There are no specific acupuncture points, just prick about an mm from the fingernail.
 3. Prick till blood comes out..
 4. If blood does not start to drip, then squeeze with your fingers.
 5. When all 10 digits is bleeding, wait a few minutes then the victim will regain consciousness.
 6. If the victim's mouth is crooked, then pull on his ears until they are red.
 7. Then prick each earlobe twice until two drops of blood comes from each earlobe.
 After a few minutes the victim should regain consciousness.


 Wait till the victim regains his normal state without any abnormal symptoms then take him to the hospital.


 Otherwise, if he was taken in the ambulance in a hurry to the hospital, the bumpy trip will cause all the capillaries in his brain to burst.

 If he could save his life, barely managing to walk, then it is by the grace of his ancestors.
 'I learned about letting blood to save life from Chinese traditional doctor, Ha Bu Ting, who lives in Sun Juke.
 Furthermore, I had practical experience with it. Therefore, I can say this method is 100% effective.
 In 1979, I was teaching in Fung Gaap College in Tai Chung.
 One afternoon, I was teaching a class when another teacher came running to my classroom and said in panting,
 'Ms Liu, come quick, our supervisor has had a stroke!'. I immediately went to the 3rd floor.
 When I saw our supervisor, Mr. Chen Fu Tien, his colour was off, his speech was slurred, his mouth was crooked - all the symptoms of a stroke.

 Immediately asked one of the practicum students to go to the pharmacy outside the school to buy a syringe, which I used to prick Mr. Chen's10 fingers tips.

 When all 10 fingers were bleeding (each with a pea-sized drop of blood), after a few minutes, Mr. Chen's face regained its colour and his eyes' spirit returned, too.

 But his mouth was still crooked. So I pulled on his ears to fill them with blood.
 When his ears became red,

 I pricked his right earlobe twice to let out two drops of blood.
 When both earlobes had two drops of blood each, a miracle happened.
 Within 3-5 minutes the shape of his mouth returned to normal and his speech became clear.

 We let him rest for a while and have a cup of hot tea, then we helped him go down the stairs, drove him to Wei ah Hospital. He rested one night and was released the next day to return to school to teach. Everything worked normally.


 There were no ill after effects.

 On the other hand, the usual stroke victim usually suffers Irreparable bursting of the brain capillaries on the way to the hospital. As a result, these victims never recover.' (Irene Liu)Therefore, stroke is the second cause of death. The lucky ones will stay alive but can remain paralyzed for life. It is such a horrible thing to happen in one's life. If we can all remember this bloodletting method and start the life saving process immediately, in a short time, the victim will be revived and regain 100% normality.

 IF POSSIBLE PLEASE FORWARD THIS AFTER READING. YOU NEVER KNOW IT MAY HELP SAVE A LIFE FROM STROKE. 
SPARE A COUPLE OF MINUTES TO FORWARD THIS MAIL. LIFE IS PRECIOUS.
  Commented by  SHRIKANT MANOHAR DANKE, Consultant, Project Management Consultancy Firm    | 08 05 2010 09:11:09 +0000
Good information posted by you, Dear Suresh. Now this will help to all of us. 
  Commented by  Rakesh K Swarnkar, Senior Consultant(Chemical), MPCON Ltd    | 08 05 2010 08:18:31 +0000
Many thanks for good informatiom
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